In 10 seconds? Despite huge advances in in-vitro fertilization (IVF) technology, still around 10% of patients suffer what is called: “recurrent implantation failure” or RIF, a condition characterized by failure to achieve a pregnancy after repeated and multiple IVF embryo transfers.

What is RIF and does it happen? Just a few days after conception happens, the healthy embryo must find a welcoming endometrium (the lining of the uterus) to implant, for pregnancy to occur. Embryo implantation is still poorly understood in research and there is no consensus in the scientific literature on how to define recurrent implantation failure and several definitions exist. Generally, RIF is diagnosed based on the number of unsuccessful IVF cycles (the process of ovarian stimulation, egg and sperm retrieval, fertilization, and embryo transfer), the number of embryos transferred, or a combination of both factors.

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