What are the genetic causes of male infertility?
Reproductive Health Male Infertility Genetics

What are the genetic causes of male infertility?

Dr. Ralph Papas
Dr. Ralph Papas

In 10 seconds? Infertility affects 15% of couples globally and half of the cases are associated with male factors. But where do these originate from? In this Digest, we'll take a look at the genetic causes of male infertility.

Why is it an important question? A better understanding would help with diagnosing and predicting the transmission of genetic alterations causing infertility from fathers using assisted reproductive technologies to their sons (especially that it raises ethical questions). It is also accepted by researchers that epigenetic factors (i.e. environmental or lifestyle factors affecting the functioning of our genes) can result in the modification of sperm and reduce their fertilizing potential. For example, a systematic review - the strongest form of scientific evidence - from November 2022 found that sperm concentration has reduced by half around the world in the past four decades (falling at about 2.6% annually), and that this was due to lifestyle factors. Apart from these, studying genetic and epigenetic factors will help to define the currently unknown causes of male infertility.

Get unlimited access to our 3-min Digests and other premium features

Choose your plan:

Personal

$99/year

✅ Includes 7-day free trial for new users
✅ Weekly Recap
✅ Daily newsletter
✅ Access 4 topic areas of your choosing
✅ Access all citations and resources
✅ Gain background knowledge with a Quick Dive
✅ The Sparrow Sessions Podcast
✅ No ads
❌ Direct access to the Expert Network
❌ Your questions - answered by an Expert Scientist
❌ 12 hours of consultations with our fabulous experts per year (that’s 1 hour per month!)
❌ Access to all topic areas as we scale the Content Library

We'll send you a reminder email 3 days before your trial ends.

Start my free trial

Professional

$3499/year

✅ Includes 7-day free trial for new users
✅ Weekly Recap
✅ Daily newsletter
✅ Access all citations and resources
✅ Gain background knowledge with a Quick Dive
✅ The Sparrow Sessions Podcast
✅ No ads
✅ Direct access to the Expert Network
✅ Your questions - answered by an Expert Scientist
✅ 12 hours of consultations with our fabulous experts per year (that’s 1 hour per month!)
✅ Access to all topic areas as we scale the Content Library

We'll send you a reminder email 3 days before your trial ends.

Start my free trial