Predicting risk of new tumors in survivors of childhood cancer
Cancer childhood cancer Retinoblastoma

Predicting risk of new tumors in survivors of childhood cancer

Flávia Oliveira Geraldes
Flávia Oliveira Geraldes

In 10 seconds? A cancer predisposition screening tool can help clinicians identify survivors of childhood cancer who are at increased risk of secondary cancers.

What’s the novelty? Subsequent neoplasms (that is, a second cancer in someone who was previously cured of the disease) are a leading cause of mortality in children and young adults who survive their original illness for more than 5 years. These account for about 50% of non-relapse related deaths in this patient group. With this new screening tool, clinicians can identify patients who are at increased risk of having a subsequent neoplasm due to what are called germline mutations. These are altered genes that increase the risk of cancer. At-risk children can be put under active monitoring, in the hope that any subsequent cancer can be detected and treated sooner.

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